![]() Ajwa date flesh and pit are also attributed for antimicrobial, antifungal, and antiviral activities. Studies have also found that Ajwa date flesh and pit have shown gastroprotective, hepatoprotective, antidiabetic, and anti-inflammatory properties due to their strong antioxidant, antimutagenic, and anticancerous activity which can be attributed due to the presence of phenolic compounds and flavonoid glycosides. Studies have found that date fruit scavenges the free radicals and prevents the occurrence of macromolecular changes in living systems. Reduction in oxidative stress which damages the intracellular structure and DNA of cell can be achieved by antioxidants, which are responsible for the removal of free radicals. Ī new approach in the management of oral cancer treatment is by antioxidant therapy. Therefore, there is a need to develop an effective treatment with potent anticancer activity and less adverse effects. Despite advancement in surgical approach and radiation therapy, the adverse effects of these treatments include anaemia, loss of appetite, and peripheral neuropathy leading to poor quality of life. The 5-year survival rate is 50%, but if detected in early stages, it is increased to 60-80%. The incidence of the disease is influenced by several factors such as use of tobacco, betel quid chewing, alcohol drinking, infection with HPV, genetics, radiation, unhealthy diet, and physical inactivity. With an increase in the prevalence and mortality rate, there were an estimated 377,713 new cases and 177,757 deaths from oral cancer in 2020. It has been documented that 90% of all oral malignancies are squamous cell carcinoma (SCC). Oral squamous cell carcinoma (OSCC) is the 6 th most common cancer around the world. In addition, combined treatment of ADF and ADP was also performed on HSC-2 cells which demonstrated higher apoptotic activity when compared to the single extract. ADP extract demonstrated higher apoptotic activity than ADF extract. ![]() HSC-2 cells were seen in the late apoptotic stage with higher doses of ADF and ADP extract. Statistical analysis of the flow cytometry assay showed that the treatment with ADF and ADP extracts had a significant apoptotic effect which occurred in a dose-dependent manner. The IC50 for the ADP was found to be 0.97 mg/ml at 24 h, and the maximum cell growth inhibition was observed at 5 mg/ml. The half inhibitory concentration (IC50) of ADF was found to be 8.69 mg/ml at 24 h, and the maximum cell growth inhibition was observed at 50 mg/ml. MTT assay demonstrated that acetone extracts of ADF and ADP were significantly cytotoxic against HSC-2 cells in a dose- and time-dependent manner. Please check with a University Enrollment Representative.Acetone extracts of ADF and ADP had the highest radical scavenging and antioxidant activities followed by the ethanolic extracts, whereas ADP appeared to have significantly higher antioxidant effects than ADF. While widely available, not all programs are available to residents of all states. Please visit the teacher licensure page or the principal licensure page for state specific requirements prior to reaching out to your state agency. Program requirements may change based upon your home state’s agency licensure requirements. Arizona certification requires candidates to pass all Arizona-specific licensure requirements, including any Arizona-specific exams (or home state equivalents if recognized by Arizona Department of Education.) After obtaining an Arizona teacher/principal certificate, candidates can then apply for licensure in their home state and may be required to complete additional testing and/or requirements at additional cost. ![]() Candidates located in a state that does not provide a direct path to licensure will be required to obtain Arizona certification first, prior to seeking licensure in their home state as an out-of-state prepared teacher/principal candidate. The following program educationally prepares students to apply for initial teacher certification in select states:īachelor of Science in Education/ Early Childhood Education (BSEd/ECH)Įducator/Principal licensure requirements vary by state.
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